3100351-69-4
Chemical Structure
TGF-β/Smad-IN-3
- CAS No.: 3100351-69-4
- Formula:C38H53F2N5O5
- Molecular Weight:697.85
InChIKey: UUNJQAFPCFRUMS-MCTJXQGZSA-N
SMILES: O=C(C1=NN=C2CN(C(CC[C@H]([C@H]3CC[C@@]4([H])[C@]5([H])[C@@H](O)C[C@]6([H])C[C@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]34C)C)=O)CCN21)NCC7=CC=CC(OC(F)F)=C7
Biological Activity: TGF-β/Smad-IN-3 (Compound 4w) is an effective TGF-β/Smad inhibitor. TGF-β/Smad-IN-3 exerts anti-pulmonary fibrosis activity by simultaneously inhibiting the TGF-β/Smad and MAPK signaling pathways. TGF-β/Smad-IN-3 significantly inhibits collagen deposition induced by TGF-β1, with its IC50 value being 3.21 μM. TGF-β/Smad-IN-3 has an IC₅₀ of 46.77 nM for the autocrine motility factor (ATX). TGF-β/Smad-IN-3 significantly reduces the expression levels of α-SMA, COL1A1 and FN in TGF-β1-induced CCC-HPF-1 cells, and effectively inhibited TGF-β1-induced cell migration. TGF-β/Smad-IN-3 can be used for the study of pulmonary fibrosis[1].
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TGF-β/Smad-IN-3 | TGF-β/Smad-IN-3 (Compound 4w) is an effective TGF-β/Smad inhibitor. TGF-β/Smad-IN-3 exerts anti-pulmonary fibrosis activity by simultaneously inhibiting the TGF-β/Smad and MAPK signaling pathways. TGF-β/Smad-IN-3 significantly inhibits collagen deposition induced by TGF-β1, with its IC50 value being 3.21 μM. TGF-β/Smad-IN-3 has an IC₅₀ of 46.77 nM for the autocrine motility factor (ATX). TGF-β/Smad-IN-3 significantly reduces the expression levels of α-SMA, COL1A1 and FN in TGF-β1-induced CCC-HPF-1 cells, and effectively inhibited TGF-β1-induced cell migration. TGF-β/Smad-IN-3 can be used for the study of pulmonary fibrosis. | |||||||||||||||||||||
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