3101627-06-6
3101627-06-6
Chemical Structure
T133
- CAS No.: 3101627-06-6
- Formula:C21H19N5O5
- Molecular Weight:421.41
InChIKey: KNRLDHMIPRBMBG-XYPYZODXSA-N
SMILES: NC1=C2C(N(C(C(C3=COC4=C3C=CC(O)=C4)=N2)=O)[C@H]5CC[C@@H](CC5)C(O)=O)=NC=N1
Biological Activity: T133 is an orally active ATP-competitive mTOR inhibitor with an IC50 of 0.34 nM and a Ki of 0.17 nM. T133 suppresses phosphorylation of AKT, S6K1, and 4EBP1. T133 inhibits cancer cell proliferation and migration, induces apoptosis, cell cycle arrest, and autophagy. T133 exhibits dose-dependent antitumor efficacy in xenograft mouse models. T133 can be used for the research of cancer, such as gastric cancer and lung cancer[1].
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T133 | T133 is an orally active ATP-competitive mTOR inhibitor with an IC50 of 0.34 nM and a Ki of 0.17 nM. T133 suppresses phosphorylation of AKT, S6K1, and 4EBP1. T133 inhibits cancer cell proliferation and migration, induces apoptosis, cell cycle arrest, and autophagy. T133 exhibits dose-dependent antitumor efficacy in xenograft mouse models. T133 can be used for the research of cancer, such as gastric cancer and lung cancer. | |||||||||||||||||||||
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