3103925-33-0
Chemical Structure
PIM-1/HDAC-IN-2
- CAS No.: 3103925-33-0
- Formula:C34H37N7O4
- Molecular Weight:607.70
InChIKey: VAMWHIVMIOLBTL-CTDFXDFQSA-N
SMILES: O=C1N(C(NC2CCN(CC2)CC3=CC=C(C=C3)/C=C/C(NO)=O)=NC4=C1C=CC=C4C5=CC6=C(N5)[C@H](NC6=O)C)C7(C)CC7
Biological Activity: PIM-1/HDAC-IN-2 is a robust PIM/HDAC inhibitor (IC50 = 0.11 μM in MV4-11cells), which exerts a synergistic antiproliferative effect through a dual mechanism of inhibiting PIM1 kinase and selectively inhibiting HDAC6. PIM-1/HDAC-IN-2 induces cell apoptosis. PIM-1/HDAC-IN-2 remarkably induces the cleavage of PARP, thereby initiating the arrest of the cell cycle in G1 phase and a reduction in S phase. PIM-1/HDAC-IN-2 demonstrates significant anticancer efficacyin the MV4-11 xenograft model without notable toxicity[1].
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PIM-1/HDAC-IN-2 | PIM-1/HDAC-IN-2 is a robust PIM/HDAC inhibitor (IC50 = 0.11 μM in MV4-11cells), which exerts a synergistic antiproliferative effect through a dual mechanism of inhibiting PIM1 kinase and selectively inhibiting HDAC6. PIM-1/HDAC-IN-2 induces cell apoptosis. PIM-1/HDAC-IN-2 remarkably induces the cleavage of PARP, thereby initiating the arrest of the cell cycle in G1 phase and a reduction in S phase. PIM-1/HDAC-IN-2 demonstrates significant anticancer efficacyin the MV4-11 xenograft model without notable toxicity. | |||||||||||||||||||||
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