3104325-26-7
3104325-26-7
Chemical Structure
LSD1-IN-48
- CAS No.: 3104325-26-7
- Formula:C18H18F2N6O3S
- Molecular Weight:436.44
InChIKey: UYFCCGCRHOIBMQ-DZGCQCFKSA-N
SMILES: O=S(C1=NC(N2C=C(CN[C@@H]3C[C@H]3C4=CC=C(F)C=C4F)N=N2)=CC(OC)=N1)(C)=O
Biological Activity: LSD1-IN-48 is a tranylcypromine-pyrimidine derivative and selective LSD1 inhibitor with a human IC50 of 7.87 nM. LSD1-IN-48 increases H3K4me1/2 histone methylation levels. LSD1-IN-48 induces apoptosis, upregulates CD86, downregulates SOX2 and CD44, inhibits proliferation in cancer cells. LSD1-IN-48 can be used for the research of acute myeloid leukemia[1].
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LSD1-IN-48 | LSD1-IN-48 is a tranylcypromine-pyrimidine derivative and selective LSD1 inhibitor with a human IC50 of 7.87 nM. LSD1-IN-48 increases H3K4me1/2 histone methylation levels. LSD1-IN-48 induces apoptosis, upregulates CD86, downregulates SOX2 and CD44, inhibits proliferation in cancer cells. LSD1-IN-48 can be used for the research of acute myeloid leukemia. | |||||||||||||||||||||
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