3104354-58-4
Chemical Structure
MptpB-IN-3
- CAS No.: 3104354-58-4
- Formula:C22H21FN4O7S2
- Molecular Weight:536.55
InChIKey: UYCMMEPQTNJVJA-IKSOVYGTSA-N
SMILES: CCCC[C@H](N1C(/C(SC1=S)=C/C2=CC(F)=C(C=C2)O[C@@H]3COC4=NC([N+]([O-])=O)=CN4C3)=O)C(O)=O
Biological Activity: MptpB-IN-3 is a selective inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with an IC50 of 0.19 μM. MptpB-IN-3 blocks MptpB-mediated inhibition of the macrophage MAPK pathway and restores the phosphorylation levels of Erk1/2 and p38. MptpB-IN-3 exhibits direct anti-tuberculosis activity against Mycobacterium tuberculosis and reduces the Mycobacterium tuberculosis load in mouse macrophages. MptpB-IN-3 can be used for tuberculosis research[1].
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MptpB-IN-3 | MptpB-IN-3 is a selective inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with an IC50 of 0.19 μM. MptpB-IN-3 blocks MptpB-mediated inhibition of the macrophage MAPK pathway and restores the phosphorylation levels of Erk1/2 and p38. MptpB-IN-3 exhibits direct anti-tuberculosis activity against Mycobacterium tuberculosis and reduces the Mycobacterium tuberculosis load in mouse macrophages. MptpB-IN-3 can be used for tuberculosis research. | |||||||||||||||||||||
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