3104731-13-4
3104731-13-4
Chemical Structure
ATM-IN-13
- CAS No.: 3104731-13-4
- Formula:C27H33N5O
- Molecular Weight:443.58
InChIKey: BKSYKZPPXBMBKW-UHFFFAOYSA-N
SMILES: CC1=NN(C2=C1C=NC3=CC=C(C=C23)C4=CC=C(N=C4)OCCCN5CCCCC5)C(C)C
Biological Activity: ATM-IN-13 (A36) is an orally active, selective ATM kinase inhibitor with a human IC50 of 0.3 nM. ATM-IN-13 blocks the ATM-mediated DNA double-strand break repair signaling pathway, reduces the phosphorylation levels of ATM and p53, and inhibits ATM-dependent DNA damage response. ATM-IN-13 can be used in the research of colorectal cancer[1].
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ATM-IN-13 | ATM-IN-13 (A36) is an orally active, selective ATM kinase inhibitor with a human IC50 of 0.3 nM. ATM-IN-13 blocks the ATM-mediated DNA double-strand break repair signaling pathway, reduces the phosphorylation levels of ATM and p53, and inhibits ATM-dependent DNA damage response. ATM-IN-13 can be used in the research of colorectal cancer. | |||||||||||||||||||||
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