3104888-50-5
Chemical Structure
P2Y1 antagonist 4
- CAS No.: 3104888-50-5
- Formula:C21H11F5N4O2
- Molecular Weight:446.33
IUPAC Name: 3-(1-(difluoromethyl)-8-oxo-6-(4-(trifluoromethoxy)phenyl)-7,8-dihydroimidazo[1,5-a]pyrazin-3-yl)benzonitrile
InChIKey: UHZINRBLLVINOP-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(F)F)N=C(C3=CC=CC(C#N)=C3)N2C=C(C4=CC=C(OC(F)(F)F)C=C4)N1
Biological Activity: P2Y1 antagonist 4 is a selective P2Y1 receptor antagonist with excellent blood-brain barrier (BBB) penetration. P2Y1 antagonist 4 inhibits P2Y1 receptor-mediated cytosolic Ca2+ increase (IC50 = 1.95 μM) and platelet aggregation (IC50 = 3.24 μM) induced by ADP in rabbit washed platelets. P2Y1 antagonist 4 significantly upregulates the level of nuclear Nrf2 protein in H2O2-treated HT22 cells. P2Y1 antagonist 4 reduces myocardial infarct size in a mouse acute myocardial infarction (MI) model. P2Y1 antagonist 4 can be used for the study of ischemic stroke and myocardial infarction[1].
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P2Y1 antagonist 4 | P2Y1 antagonist 4 is a selective P2Y1 receptor antagonist with excellent blood-brain barrier (BBB) penetration. P2Y1 antagonist 4 inhibits P2Y1 receptor-mediated cytosolic Ca2+ increase (IC50 = 1.95 μM) and platelet aggregation (IC50 = 3.24 μM) induced by ADP in rabbit washed platelets. P2Y1 antagonist 4 significantly upregulates the level of nuclear Nrf2 protein in H2O2-treated HT22 cells. P2Y1 antagonist 4 reduces myocardial infarct size in a mouse acute myocardial infarction (MI) model. P2Y1 antagonist 4 can be used for the study of ischemic stroke and myocardial infarction. | |||||||||||||||||||||
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