3106013-91-3
3106013-91-3
Chemical Structure
JNJ-78911118
- CAS No.: 3106013-91-3
- Formula:C19H16ClF2N5O2
- Molecular Weight:419.81
InChIKey: YPXUKPNZQTWCRR-UHFFFAOYSA-N
SMILES: CC1=NC(C(NCC2=CC=CN=C2)=O)=CN=C1OCC(F)(F)C3=CC(Cl)=CC=N3
Biological Activity: JNJ-78911118 is a potent, brain-penetrant, selective GluN2A antagonist (IC50 = 44 nM). JNJ-78911118 shows >200-fold selectivity against GluN1/2B, 2C and 2D receptors. JNJ-78911118 functions as a negative allosteric modulator (NAM) by insurmountably suppressing glutamate efficacy and reducing glycine potency at GluN1/2A receptors. JNJ-78911118 produces profound pharmacodynamic effects in vivo. JNJ-78911118 can be used for depression research[1].
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JNJ-78911118 | 99.38% | JNJ-78911118 is a potent, brain-penetrant, selective GluN2A antagonist (IC50 = 44 nM). JNJ-78911118 shows >200-fold selectivity against GluN1/2B, 2C and 2D receptors. JNJ-78911118 functions as a negative allosteric modulator (NAM) by insurmountably suppressing glutamate efficacy and reducing glycine potency at GluN1/2A receptors. JNJ-78911118 produces profound pharmacodynamic effects in vivo. JNJ-78911118 can be used for depression research. | ||||||||||||||||||||
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