3107107-66-1
3107107-66-1
Chemical Structure
NLRP3-IN-99
- CAS No.: 3107107-66-1
- Formula:C27H26N2O5S
- Molecular Weight:490.57
InChIKey: KXKVRSOERONGSJ-UHFFFAOYSA-N
SMILES: O=C(NS(=O)(C1=CC(C(C)(C)O)=CO1)=O)NC2=C(C3=CC4=C(C=CC=C4)C=C3)C=CC5=C2CCC5
Biological Activity: NLRP3-IN-99 is an orally active NLRP3 inflammasome inhibitor, IC50 = 0.019 μM. NLRP3-IN-99 binds to the NLRP3 NACHT domain with a human Kd value of 6.9 nM, blocking inflammasome assembly and activation. NLRP3-IN-99 blocks ASC oligomerization and the assembly of NLRP3 with ASC and NEK7, inhibiting NLRP3-driven IL‑1β secretion. NLRP3-IN-99 can be used for research on NLRP3-related diseases, such as gout[1].
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NLRP3-IN-99 | NLRP3-IN-99 is an orally active NLRP3 inflammasome inhibitor, IC50 = 0.019 μM. NLRP3-IN-99 binds to the NLRP3 NACHT domain with a human Kd value of 6.9 nM, blocking inflammasome assembly and activation. NLRP3-IN-99 blocks ASC oligomerization and the assembly of NLRP3 with ASC and NEK7, inhibiting NLRP3-driven IL‑1β secretion. NLRP3-IN-99 can be used for research on NLRP3-related diseases, such as gout. | |||||||||||||||||||||
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