3107476-89-8
3107476-89-8
Chemical Structure
MS152
- CAS No.: 3107476-89-8
- Formula:C22H31N3O3
- Molecular Weight:385.50
InChIKey: SNDNHGBMPQNJKI-UHFFFAOYSA-N
SMILES: COC1=CC2=C(C=C1OCCCN3CCCC3)N=C(N)C=C2C4CCOCC4
Biological Activity: MS152 is an orally active, blood-brain barrier penetrant inhibitor of EHMT2/G9a and EHMT1/GLP, with IC50s of 76 nM and 126 nM, repsectively. MS152 reduces H3K9me2 levels and reactivates maternally silenced Prader-Willi syndrome (PWS) genes. MS152 significantly improves perinatal lethality and growth retardation in mouse models, and is applicable to research related to Prader-Willi syndrome[1].
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MS152 | 99.36% | MS152 is an orally active, blood-brain barrier penetrant inhibitor of EHMT2/G9a and EHMT1/GLP, with IC50s of 76 nM and 126 nM, repsectively. MS152 reduces H3K9me2 levels and reactivates maternally silenced Prader-Willi syndrome (PWS) genes. MS152 significantly improves perinatal lethality and growth retardation in mouse models, and is applicable to research related to Prader-Willi syndrome. | ||||||||||||||||||||
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