3107483-12-2
3107483-12-2
Chemical Structure
sEH inhibitor-19
- CAS No.: 3107483-12-2
- Formula:C28H28F3N3O4
- Molecular Weight:527.53
InChIKey: QLVMEJODLSQJTN-XMMPIXPASA-N
SMILES: O=C(NCC1=CC=C(OC(F)(F)F)C=C1)NC2=CC(C3)=C(C=C2)C[C@@]4([H])N3CCC5=C4C=C(OC)C(OC)=C5
Biological Activity: sEH inhibitor-19 (Compound (R)-14i) is an orally active inhibitor for soluble epoxide hydrolase (sEH) with an IC50 of 1.2 nM. sEH inhibitor-19 inhibits the expression of TNF-α and IL-6, exhibits anti-inflammatory activity in mouse acute pancreatitis or Carrageenan (HY-125474)-induced edema models[1].
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sEH inhibitor-19 | sEH inhibitor-19 (Compound (R)-14i) is an orally active inhibitor for soluble epoxide hydrolase (sEH) with an IC50 of 1.2 nM. sEH inhibitor-19 inhibits the expression of TNF-α and IL-6, exhibits anti-inflammatory activity in mouse acute pancreatitis or Carrageenan (HY-125474)-induced edema models. | |||||||||||||||||||||
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