3108258-69-8
Chemical Structure
PPARα/δ agonist 4
- CAS No.: 3108258-69-8
- Formula:C22H24N4O6
- Molecular Weight:440.45
InChIKey: LMYZCICULNQTHJ-UHFFFAOYSA-N
SMILES: CC1=CC(CN2N=NN(C2=O)C3=CC4=C(OCCO4)C=C3)=CC(C)=C1OC(C)(C(O)=O)C
Biological Activity: PPARα/δ agonist 4 is a potent orally active and selective dual peroxisome proliferator-activated receptor (PPAR) α/δ agonist with EC50s of 0.36 and 1.31 nM, respectively. PPARα/δ agonist 4 exhibits >123-fold selectivity over PPARγ (EC50 = 160.84 nM). PPARα/δ agonist 4 upregulates expression of downstream fatty acid oxidation genes PDK4, CPT1A, and ACADVL. PPARα/δ agonist 4 can be used for the research of metabolic dysfunction-associated steatohepatitis[1].
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PPARα/δ agonist 4 | PPARα/δ agonist 4 is a potent orally active and selective dual peroxisome proliferator-activated receptor (PPAR) α/δ agonist with EC50s of 0.36 and 1.31 nM, respectively. PPARα/δ agonist 4 exhibits >123-fold selectivity over PPARγ (EC50 = 160.84 nM). PPARα/δ agonist 4 upregulates expression of downstream fatty acid oxidation genes PDK4, CPT1A, and ACADVL. PPARα/δ agonist 4 can be used for the research of metabolic dysfunction-associated steatohepatitis. | |||||||||||||||||||||
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