3108487-29-9
3108487-29-9
Chemical Structure
SMI-10B13
- CAS No.: 3108487-29-9
- Formula:C23H16N2O3
- Molecular Weight:368.38
IUPAC Name: (E)-3-(4,5-di(1H-indol-6-yl)furan-2-yl)acrylic acid
InChIKey: AXPSFIMCIARDSQ-AATRIKPKSA-N
SMILES: O=C(/C=C/C1=CC(C2=CC3=C(C=C2)C=CN3)=C(O1)C4=CC=C5C=CNC5=C4)O
Biological Activity: SMI-10B13 is an Oncostatin M (OSM) inhibitor with a KD of 6.6 μM. SMI-10B13 inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines (IC50 = 136 and 164 nM, respectively). SMI-10B13 shows anti-tumor effect in human breast cancer mice models[1].
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SMI-10B13 | 99.67% | SMI-10B13 is an Oncostatin M (OSM) inhibitor with a KD of 6.6 μM. SMI-10B13 inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines (IC50 = 136 and 164 nM, respectively). SMI-10B13 shows anti-tumor effect in human breast cancer mice models. | ||||||||||||||||||||
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