3108878-05-0
Chemical Structure
RANKL-IN-1
- CAS No.: 3108878-05-0
- Formula:C40H55N5O
- Molecular Weight:621.90
IUPAC Name: ((2R,4aS,6aS,6bS,16aS)-2,4a,6a,6b,9,16a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,16,16a,16b-dodecahydrochryseno[1,2-g]quinoxalin-2-yl)(4-(piperazin-1-yl)piperidin-1-yl)methanone
InChIKey: VZVANJSVYWTLOD-GHKFEZRCSA-N
SMILES: CC1=C(C2=CC3=NC=CN=C31)C=C[C@@]4(C2=CC[C@@]5([C@@]4(CC[C@@]6([C@H]5C[C@](C(N7CCC(CC7)N8CCNCC8)=O)(CC6)C)C)C)C)C
Biological Activity: RANKL-IN-1 is a selective and orally active Receptor Activator of Nuclear Factor-κ B Ligand (RANKL) inhibitor with a KD value of 7.6 μM. RANKL-IN-1 exhibits inhibitory activity and selectivity against osteoclastogenesis with an IC50 value of 0.07 μM and SI of 82.57. RANKL-IN-1binds directly to RANKL and blocks the RANKL-induced activation of the NF-κB and MAPK pathways. RANKL-IN-1 can be used for the research of metabolic disease, such as osteoporosis[1].
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RANKL-IN-1 | RANKL-IN-1 is a selective and orally active Receptor Activator of Nuclear Factor-κ B Ligand (RANKL) inhibitor with a KD value of 7.6 μM. RANKL-IN-1 exhibits inhibitory activity and selectivity against osteoclastogenesis with an IC50 value of 0.07 μM and SI of 82.57. RANKL-IN-1binds directly to RANKL and blocks the RANKL-induced activation of the NF-κB and MAPK pathways. RANKL-IN-1 can be used for the research of metabolic disease, such as osteoporosis. | |||||||||||||||||||||
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