3109469-27-1
Chemical Structure
CHI3L1-IN-3
- CAS No.: 3109469-27-1
- Formula:C30H33N3O6S
- Molecular Weight:563.66
IUPAC Name: 2-((3-(3,4-dimethoxyphenethyl)-6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)thio)-N-(4-ethylphenyl)acetamide
InChIKey: WNTXUYNQYVAHHX-UHFFFAOYSA-N
SMILES: COC(C(OC)=C1)=CC(C2=O)=C1N=C(SCC(NC3=CC=C(CC)C=C3)=O)N2CCC4=CC=C(OC)C(OC)=C4
Biological Activity: CHI3L1-IN-3 is a CHI3L1 inhibitor. CHI3L1-IN-3 binds to CHI3L1 with Kds of 13.76 μM and 13.5 μM in MST and SPR assays, respectively. CHI3L1-IN-3 demonstrates extended plasma half-lives and microsomal stability, along with reduced intrinsic clearance. CHI3L1-IN-3 induces dose-dependent cytotoxicity, reduces spheroid mass and inhibits migration in a 3D multicellular glioblastoma (GBM) spheroid model. CHI3L1-IN-3 can be used for the study of GBM[1].
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CHI3L1-IN-3 | 98.95% | CHI3L1-IN-3 is a CHI3L1 inhibitor. CHI3L1-IN-3 binds to CHI3L1 with Kds of 13.76 μM and 13.5 μM in MST and SPR assays, respectively. CHI3L1-IN-3 demonstrates extended plasma half-lives and microsomal stability, along with reduced intrinsic clearance. CHI3L1-IN-3 induces dose-dependent cytotoxicity, reduces spheroid mass and inhibits migration in a 3D multicellular glioblastoma (GBM) spheroid model. CHI3L1-IN-3 can be used for the study of GBM. | ||||||||||||||||||||
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