3109470-77-8
3109470-77-8
Chemical Structure
SH458
- CAS No.: 3109470-77-8
- Formula:C28H30N2O4
- Molecular Weight:458.55
InChIKey: SSOYPOOEYWPQMD-NOSDFKEYSA-N
SMILES: O=C(C1=CN=CC=C1)O[C@H]2CC[C@@]3([H])[C@]4([H])C(C=C5C(C)(C)C(C(C#N)=C[C@]5(C)[C@@]4([H])CC[C@@]32C)=O)=O
Biological Activity: SH458 is an orally active anti-triple-negative breast cancer compound. SH458 significantly upregulates the expression of unfolded protein response (UPR)-related proteins, including p-eIF2α and p-IRE1α. SH458 induces Apoptosis, G2/M phase arrest, oxidative stress with increased ROS, DNA damage, and checkpoint kinase activation[1].
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SH458 | SH458 is an orally active anti-triple-negative breast cancer compound. SH458 significantly upregulates the expression of unfolded protein response (UPR)-related proteins, including p-eIF2α and p-IRE1α. SH458 induces Apoptosis, G2/M phase arrest, oxidative stress with increased ROS, DNA damage, and checkpoint kinase activation. | |||||||||||||||||||||
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