31105-03-0
Chemical Structure
Fructose-phenylalanine
Synonym(s): Fru-Phe
- CAS No.: 31105-03-0
- Formula:C15H21NO7
- Molecular Weight:327.33
IUPAC Name: (3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl L-phenylalaninate
InChIKey: WZWDUEKBAIXVCC-IGHBBLSQSA-N
SMILES: OC[C@@H](O)[C@@H](O)[C@H](O)C(CN[C@H](C(O)=O)CC1=CC=CC=C1)=O
Biological Activity: Fructose-phenylalanine (Fru-Phe) is a non-competitive angiotensin-converting enzyme (ACE) inhibitor (IC50 =0.19 mM) with antioxidant activities. Fructose-phenylalanine forms a stable complex with Zn2+ ions at the ACE active site, blocking the conversion of angiotensin I to II and thereby lowering blood pressure. Fructose-phenylalanine is promising for research of cardiovascular diseases[1][2].
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Fructose-phenylalanine | Fructose-phenylalanine (Fru-Phe) is a non-competitive angiotensin-converting enzyme (ACE) inhibitor (IC50 =0.19 mM) with antioxidant activities. Fructose-phenylalanine forms a stable complex with Zn2+ ions at the ACE active site, blocking the conversion of angiotensin I to II and thereby lowering blood pressure. Fructose-phenylalanine is promising for research of cardiovascular diseases. | |||||||||||||||||||||
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References
- [1]. Johnson GH, et al. Nutritional implications of the Maillard reaction: the availability of fructose-phenylalanine to the chick. J Nutr. 1977 Sep;107(9):1659-64. [Content Brief]
- [2]. Jiahao Yu, et al. Potential contribution of Amadori compounds to antioxidant and angiotensin I converting enzyme inhibitory activities of raw and black garlic. LWT, Volume 129, 2020, 109553, ISSN 0023-6438,
