3111620-80-2
Chemical Structure
XJ-4-85
- CAS No.: 3111620-80-2
- Formula:C31H28F4N4O4S
- Molecular Weight:628.64
InChIKey: KSHLCMQEMQOOME-UHFFFAOYSA-N
SMILES: FC1=CC=C(/C(C2=CC=C(F)C(F)=C2)=C3CCN(CCCCC4=CN(S(=O)(C5=CC=C(OCO6)C6=C5)=O)N=N4)CC\3)C=C1F
Biological Activity: XJ-4-85 is a covalent activator and precursor compound targeting PFKL (EC50=56 μM in human PFKL). XJ-4-85 activates glycolysis, increases FBP production and glycolytic flux, and enhances LPS-stimulated proinflammatory cytokine release in macrophages. XJ-4-85 causes long-chain acylcarnitine accumulation, metabolic stress, and cytotoxicity through the release of the active payload XJ-4-119 targeting CPT2. XJ-4-85 exhibits broad and selective cytotoxicity across multiple cancer cell lines and is useful for melanoma research[1].
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XJ-4-85 | XJ-4-85 is a covalent activator and precursor compound targeting PFKL (EC50=56 μM in human PFKL). XJ-4-85 activates glycolysis, increases FBP production and glycolytic flux, and enhances LPS-stimulated proinflammatory cytokine release in macrophages. XJ-4-85 causes long-chain acylcarnitine accumulation, metabolic stress, and cytotoxicity through the release of the active payload XJ-4-119 targeting CPT2. XJ-4-85 exhibits broad and selective cytotoxicity across multiple cancer cell lines and is useful for melanoma research. | |||||||||||||||||||||
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