3112325-99-9
3112325-99-9
Chemical Structure
BRD4-IN-12
- CAS No.: 3112325-99-9
- Formula:C21H24N4O4S
- Molecular Weight:428.50
InChIKey: JQDMWLMDNPYSOP-UHFFFAOYSA-N
SMILES: CCS(=O)(NC1=CC(C2=CN(C(C(NC)=C2)=O)C)=C(C=C1)OC3=CN=CC=C3C)=O
Biological Activity: BRD4-IN-12 is a potent and orally active BRD4 inhibitor with an IC50 of 7.9 nM. BRD4-IN-12 downregulates the expression of c-MYC, BCL-2, CDK4 and upregulates p21. BRD4-IN-12 inhibits tumor cell proliferation and promotes apoptosis. BRD4-IN-12 exhibits excellent antitumor effects in the HCT-116 colorectal cancer xenograft model. BRD4-IN-12 can be used for the study of colorectal cancer (CRC)[1].
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BRD4-IN-12 | BRD4-IN-12 is a potent and orally active BRD4 inhibitor with an IC50 of 7.9 nM. BRD4-IN-12 downregulates the expression of c-MYC, BCL-2, CDK4 and upregulates p21. BRD4-IN-12 inhibits tumor cell proliferation and promotes apoptosis. BRD4-IN-12 exhibits excellent antitumor effects in the HCT-116 colorectal cancer xenograft model. BRD4-IN-12 can be used for the study of colorectal cancer (CRC). | |||||||||||||||||||||
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