3112500-81-6
3112500-81-6
Chemical Structure
WC-2
- CAS No.: 3112500-81-6
- Formula:C21H21F3N2O4S
- Molecular Weight:454.46
InChIKey: PABWQICOBPDFSP-YPOUMIDOSA-N
SMILES: O=C(N[C@@H](C1CC1)/C=C(F)/S(C)(=O)=O)C2=CC=C(C(C)(F)F)C(OC3=CC=CC=C3)=N2
Biological Activity: WC-2 is an ATP-competitive covalent WRN helicase inhibitor with IC50 values of 252 nM and 250 nM. WC-2 binds covalently to Cys727 of WRN helicase and maintains conformational complementarity with this protein. WC-2 induces p21 transcription as part of the DNA damage response, and selectively reduces the viability of MSI-H cancer cells. WC-2 can be used in the research of MSI-H tumors[1].
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WC-2 | WC-2 is an ATP-competitive covalent WRN helicase inhibitor with IC50 values of 252 nM and 250 nM. WC-2 binds covalently to Cys727 of WRN helicase and maintains conformational complementarity with this protein. WC-2 induces p21 transcription as part of the DNA damage response, and selectively reduces the viability of MSI-H cancer cells. WC-2 can be used in the research of MSI-H tumors. | |||||||||||||||||||||
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