3113145-60-8
Chemical Structure
Am-Ka12K4
- CAS No.: 3113145-60-8
- Formula:C126H255N11O5
- Molecular Weight:2004.44
InChIKey: PKVMOSBDOJWBBQ-JMIICXCMSA-N
SMILES: CCCCCCCCCCCCN(CCCC[C@H](NC([C@H](CCCCN)N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)CCCCCCCCCCCC
Biological Activity: Am-Ka12K4 is a weakly positively charged peptide-based ionizable lipid. Am-Ka12K4 induces membrane disruption under endosomal pH conditions and possesses high lipid fusion capacity. Am-Ka12K4 forms tightly packed, stable lipid nanoparticles. Am-Ka12K4 mediates in vivo mRNA delivery, exhibits inherent liver tropism, and can be modified to adjust organ tropism, enabling selective mRNA delivery to the spleen, lung, or thymus. Am-Ka12K4 is applicable to research related to repetitive mild traumatic brain injury[1][2].
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Am-Ka12K4 | Am-Ka12K4 is a weakly positively charged peptide-based ionizable lipid. Am-Ka12K4 induces membrane disruption under endosomal pH conditions and possesses high lipid fusion capacity. Am-Ka12K4 forms tightly packed, stable lipid nanoparticles. Am-Ka12K4 mediates in vivo mRNA delivery, exhibits inherent liver tropism, and can be modified to adjust organ tropism, enabling selective mRNA delivery to the spleen, lung, or thymus. Am-Ka12K4 is applicable to research related to repetitive mild traumatic brain injury. | |||||||||||||||||||||
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References
- [1]. Lin Y, et al. Tissue-specific mRNA delivery and prime editing with peptide-ionizable lipid nanoparticles. Nature materials. 2026 Jan;25(1):133-145. [Content Brief]
- [2]. Yu X, et al. Nose-to-Brain Delivery of mRNA-Loaded Lipid Nanoparticles Bypasses the Blood-Brain Barrier for Effective Brain Disease Therapy. ACS nano. 2026 Jun 02;20(21):15589-15605. [Content Brief]
