3113312-38-9
Chemical Structure
Anti-neuroinflammation agent-4
- CAS No.: 3113312-38-9
- Formula:C31H33N3O3
- Molecular Weight:495.61
InChIKey: TTYOIELBELGQPA-UHFFFAOYSA-N
SMILES: COC1=C2C(OCCC3=C2NC(C4=CC=CC=C4)=NC3C5=CC=C(N6CCCCC6)C=C5)=CC(OC)=C1
Biological Activity: Anti-neuroinflammation agent-4 is a blood-brain barrier-penetrating inhibitor of IκBα, NLRP3, and NF-κB p65. Anti-neuroinflammation agent-4 exerts anti-neuroinflammatory effects by inhibiting IκBα phosphorylation, reducing NLRP3 and caspase-1 expression, and suppressing p65 phosphorylation and its nuclear translocation, thereby decreasing the release of inflammatory mediators such as ROS, NO, IL-1β, IL-6, TNF-α, and IL-18 in microglia. Anti-neuroinflammation agent-4 can be used for research on neuroinflammation[1].
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Anti-neuroinflammation agent-4 | Anti-neuroinflammation agent-4 is a blood-brain barrier-penetrating inhibitor of IκBα, NLRP3, and NF-κB p65. Anti-neuroinflammation agent-4 exerts anti-neuroinflammatory effects by inhibiting IκBα phosphorylation, reducing NLRP3 and caspase-1 expression, and suppressing p65 phosphorylation and its nuclear translocation, thereby decreasing the release of inflammatory mediators such as ROS, NO, IL-1β, IL-6, TNF-α, and IL-18 in microglia. Anti-neuroinflammation agent-4 can be used for research on neuroinflammation. | |||||||||||||||||||||
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