3114128-41-2
Chemical Structure
CL-NC
- CAS No.: 3114128-41-2
- Formula:C36H33N3O5
- Molecular Weight:587.66
InChIKey: DPNHCEQKJNINRM-IMGQKSAJSA-N
SMILES: COC1(C2([C@@H]3C[C@H]4C[C@H](C[C@@H]2C4)C3)OO1)C5=CC(OCCC[N+]#[C-])=CC=C5/C=C/C6=C/C(C(C=CC=C7)=C7O6)=C(C#N)/C#N
Biological Activity: CL-NC is a chemiluminescent probe used for in vivo imaging of N-methyl-D-aspartate receptors (NMDARs), and its detection mechanism relies on bioorthogonal activation achieved via a tetrazine-triggered click-to-release reaction. The isonitrile group of CL-NC undergoes a click reaction with tetrazine, followed by hydrolysis and β-elimination to release a phenoxide anion, which induces the departure of adamantane and generates chemiluminescence. CL-NC has a maximum absorption wavelength of approximately 425 nm, a maximum fluorescence emission wavelength of approximately 670 nm, and a maximum chemiluminescence emission wavelength of 710 nm. When used in combination with Tz-IFDL (HY-D3369), an NMDAR ligand conjugated with tetrazine, CL-NC enables targeted imaging of NMDARs in living cells, as well as in the brain and spinal cord of living mice[1].
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CL-NC | CL-NC is a chemiluminescent probe used for in vivo imaging of N-methyl-D-aspartate receptors (NMDARs), and its detection mechanism relies on bioorthogonal activation achieved via a tetrazine-triggered click-to-release reaction. The isonitrile group of CL-NC undergoes a click reaction with tetrazine, followed by hydrolysis and β-elimination to release a phenoxide anion, which induces the departure of adamantane and generates chemiluminescence. CL-NC has a maximum absorption wavelength of approximately 425 nm, a maximum fluorescence emission wavelength of approximately 670 nm, and a maximum chemiluminescence emission wavelength of 710 nm. When used in combination with Tz-IFDL (HY-D3369), an NMDAR ligand conjugated with tetrazine, CL-NC enables targeted imaging of NMDARs in living cells, as well as in the brain and spinal cord of living mice. | |||||||||||||||||||||
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