3114314-82-5
Chemical Structure
VCP/p97 IN-4
- CAS No.: 3114314-82-5
- Formula:C28H29F2N3
- Molecular Weight:445.55
InChIKey: YOLVAZTUYZNRJM-QHCPKHFHSA-N
SMILES: FC1=CC=C(C=C1)C(C2=CC=C(C=C2)F)CCCNC[C@@H]3CC4=C(NC5=C4C=CC=C5)CN3
Biological Activity: VCP/p97 IN-4 is a p97/VCP inhibitor (Kd=14.99 μM) targeting the allosteric site of the D1-D2 domain. VCP/p97 IN-4 inhibits the ATPase activity of VCP/p97 in an ATP concentration-independent manner. VCP/p97 IN-4 induces apoptosis, autophagy, mitochondrial stress and mitochondrial membrane depolarization. VCP/p97 IN-4 inhibits the growth of patient-derived colorectal cancer organoids and exhibits in vivo efficacy in a colorectal cancer xenograft mouse model. VCP/p97 IN-4 can be used for the research of colorectal cancer[1].
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VCP/p97 IN-4 | VCP/p97 IN-4 is a p97/VCP inhibitor (Kd=14.99 μM) targeting the allosteric site of the D1-D2 domain. VCP/p97 IN-4 inhibits the ATPase activity of VCP/p97 in an ATP concentration-independent manner. VCP/p97 IN-4 induces apoptosis, autophagy, mitochondrial stress and mitochondrial membrane depolarization. VCP/p97 IN-4 inhibits the growth of patient-derived colorectal cancer organoids and exhibits in vivo efficacy in a colorectal cancer xenograft mouse model. VCP/p97 IN-4 can be used for the research of colorectal cancer. | |||||||||||||||||||||
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