3114596-57-2
3114596-57-2
Chemical Structure
A2AAR antagonist 4
- CAS No.: 3114596-57-2
- Formula:C19H21N5O3
- Molecular Weight:367.40
IUPAC Name: (2R,3R)-2-(6-amino-8-(furan-2-yl)-2-(hex-1-yn-1-yl)-9H-purin-9-yl)tetrahydrofuran-3-ol
InChIKey: HETCKQIBHYHPBR-CWTRNNRKSA-N
SMILES: O[C@@H]1CCO[C@H]1N2C3=C(N=C2C4=CC=CO4)C(N)=NC(C#CCCCC)=N3
Biological Activity: A2AAR antagonist 4 is an orally active A2A Adenosine receptor antagonist with a Ki of 0.36 nM and a KB of 1 nM at hA2AAR. A2AAR antagonist 4 fully inhibits hA2AAR and hA2bAR at 10 μM. A2AAR antagonist 4 can be used for research of cancer, such as MC38 tiumor[1].
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A2AAR antagonist 4 | A2AAR antagonist 4 is an orally active A2A Adenosine receptor antagonist with a Ki of 0.36 nM and a KB of 1 nM at hA2AAR. A2AAR antagonist 4 fully inhibits hA2AAR and hA2bAR at 10 μM. A2AAR antagonist 4 can be used for research of cancer, such as MC38 tiumor. | |||||||||||||||||||||
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