3115361-08-2
3115361-08-2
Chemical Structure
Nav1.8-IN-26
- CAS No.: 3115361-08-2
- Formula:C24H21DF8N2O5
- Molecular Weight:571.44
InChIKey: STMGCURONOJNMJ-WLJATYLHSA-N
SMILES: C[C@H]1[C@H]([C@@H](O[C@@]1(C)C(F)(F)F)C2=NC3=C(N2)C=C(C(F)=C3)OC[C@@H](CO)O)C4=C(C(F)=C(C=C4)F)OC(F)([2H])F
Biological Activity: Nav1.8-IN-26 is an orally active NaV1.8 inhibitor (IC50 = 3.0 nM). Nav1.8-IN-26 exhibits selectivity over other sodium channel subtypes, while inhibiting the hERG potassium channel (IC50 = 16 μM), and produces analgesic effects in rat pain models. Nav1.8-IN-26 can be used for research on postoperative pain and inflammatory pain[1].
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Nav1.8-IN-26 | Nav1.8-IN-26 is an orally active NaV1.8 inhibitor (IC50 = 3.0 nM). Nav1.8-IN-26 exhibits selectivity over other sodium channel subtypes, while inhibiting the hERG potassium channel (IC50 = 16 μM), and produces analgesic effects in rat pain models. Nav1.8-IN-26 can be used for research on postoperative pain and inflammatory pain. | |||||||||||||||||||||
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