3115765-38-0
3115765-38-0
Chemical Structure
dAurAB2
- CAS No.: 3115765-38-0
- Formula:C52H62BrN11O8
- Molecular Weight:1049.02
InChIKey: MLNBHVAPALPWDP-UHFFFAOYSA-N
SMILES: O=C(NCCCCCCCCCCCC(N1CCN(C2=CC=C(C3=NC4=C(N5CCN(CC6=NOC(C)=C6)CC5)C(Br)=CN=C4N3)C=C2)CC1)=O)COC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O
Biological Activity: dAurAB2 is a potent Aurora-A/Aurora-B PROTAC degrader with DC50 values of 59 nM and 39 nM, respectively. dAurAB2 induces ubiquitination and proteasomal degradation of Aurora-A kinase and Aurora-B kinase, and indirectly reduces N-Myc protein levels. dAurAB2 can be used in studies related to neuroblastoma[1][2].
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dAurAB2 | 98.61% | dAurAB2 is a potent Aurora-A/Aurora-B PROTAC degrader with DC50 values of 59 nM and 39 nM, respectively. dAurAB2 induces ubiquitination and proteasomal degradation of Aurora-A kinase and Aurora-B kinase, and indirectly reduces N-Myc protein levels. dAurAB2 can be used in studies related to neuroblastoma. | ||||||||||||||||||||
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References
- [1]. Nelson SE, et al. Development of Dual Aurora-A and Aurora-B Degrading PROTACs for -Amplified Neuroblastoma. ChemMedChem. 2025 Mar 03;20(5):e202400703. [Content Brief]
- [2]. Pogash S, et al. Razing the scaffolding: the elimination of non-catalytic functions of kinases through targeted protein degradation. RSC medicinal chemistry. 2025 Jul 16;16(7):2958-2973. [Content Brief]
