3117528-53-4
Chemical Structure
Hsp90-IN-48
- CAS No.: 3117528-53-4
- Formula:C45H43FN6O8
- Molecular Weight:814.86
InChIKey: QAKHVUOQLFJROC-UHFFFAOYSA-N
SMILES: OC(C(C(C)C)=C1)=CC(O)=C1C2=C(C3=CC=C(CN4CCOCC4)C=C3)C(C(NCC(OC5=CC=C(NC6=C7CCN8C6N(C)C(C=CC(F)=C9)=C9C8=O)C7=C5)=O)=O)=NO2
Biological Activity: Hsp90-IN-48 is an orally active Hsp90 inhibitor with an IC50 of 19.4 nM. Hsp90-IN-48 improves tumor-cell uptake and intracellular active-component release, and suppresses tumor metastasis. Hsp90-IN-48 induces G2/M phase cell cycle arrest and tumor cell apoptosis whlie simultaneously inhibits Top1/Top2 activity. Hsp90-IN-48 inhibits tumor growth and can be used for colon cancer research[1].
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Hsp90-IN-48 | Hsp90-IN-48 is an orally active Hsp90 inhibitor with an IC50 of 19.4 nM. Hsp90-IN-48 improves tumor-cell uptake and intracellular active-component release, and suppresses tumor metastasis. Hsp90-IN-48 induces G2/M phase cell cycle arrest and tumor cell apoptosis whlie simultaneously inhibits Top1/Top2 activity. Hsp90-IN-48 inhibits tumor growth and can be used for colon cancer research. | |||||||||||||||||||||
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