3117543-49-1
3117543-49-1
Chemical Structure
JYQ-164
- CAS No.: 3117543-49-1
- Formula:C23H26N6O5S2
- Molecular Weight:530.62
InChIKey: OIDCEUZVEWFKMP-QGZVFWFLSA-N
SMILES: O=C([C@H]1CN(C#N)CC1)NC(S2)=NC3=C2CN(C(C4=CC=CC(S(=O)(N5CCOCC5)=O)=C4)=O)CC3
Biological Activity: JYQ-164 is a cell-permeable covalent PARK7 inhibitor (human IC50 = 21 nM). JYQ-164 covalently modifies the key active-site cysteine and inhibits PARK7 enzymatic activity, shows selectivity for PARK7 in cysteine-activity-based proteomic profiling, and does not interfere with deubiquitinase activities including UCHL1. JYQ-164 can be used for PARK7-related research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JYQ-164 | 99.43% | JYQ-164 is a cell-permeable covalent PARK7 inhibitor (human IC50 = 21 nM). JYQ-164 covalently modifies the key active-site cysteine and inhibits PARK7 enzymatic activity, shows selectivity for PARK7 in cysteine-activity-based proteomic profiling, and does not interfere with deubiquitinase activities including UCHL1. JYQ-164 can be used for PARK7-related research. | ||||||||||||||||||||
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References
- [1]. Jia Y, et al. Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell. Journal of medicinal chemistry. 2024 May 23;67(10):7935-7953. [Content Brief]
- [2]. Jia Y, et al. Development of potent and cell-permeable chemical tools for PARK7. [Content Brief]
