3118064-89-1
Chemical Structure
Anti-inflammatory agent 125
- CAS No.: 3118064-89-1
- Formula:C18H12F2N4O2S
- Molecular Weight:386.38
InChIKey: IQKUVBFRSWDLOW-UHFFFAOYSA-N
SMILES: FC1=CC(F)=CC=C1S(NC(C=CC=C2)=C2C3=C4C(NC=C4)=NC=N3)(=O)=O
Biological Activity: Anti-inflammatory agent 125 is an anti-inflammatory agent. Anti-inflammatory agent 125 inhibits the phosphorylation of p65 and IκBα induced by LPS (HY-D1056) stimulation, slows IκBα degradation, and inhibits the phosphorylation of p38 and ERK1/2, thereby simultaneously intervening in the NF-κB and MAPK pathways and reducing the production of IL-6 and IL-8. Anti-inflammatory agent 125 alleviates lung inflammation and edema and attenuates inflammatory cell infiltration in mouse models. Anti-inflammatory agent 125 exhibits low cytotoxicity in cells in vitro, with a favorable safety profile. Anti-inflammatory agent 125 can be used for research on acute lung injury and inflammation-related studies[1].
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Anti-inflammatory agent 125 | Anti-inflammatory agent 125 is an anti-inflammatory agent. Anti-inflammatory agent 125 inhibits the phosphorylation of p65 and IκBα induced by LPS (HY-D1056) stimulation, slows IκBα degradation, and inhibits the phosphorylation of p38 and ERK1/2, thereby simultaneously intervening in the NF-κB and MAPK pathways and reducing the production of IL-6 and IL-8. Anti-inflammatory agent 125 alleviates lung inflammation and edema and attenuates inflammatory cell infiltration in mouse models. Anti-inflammatory agent 125 exhibits low cytotoxicity in cells in vitro, with a favorable safety profile. Anti-inflammatory agent 125 can be used for research on acute lung injury and inflammation-related studies. | |||||||||||||||||||||
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