3118558-91-8
3118558-91-8
Chemical Structure
BPR1M492
- CAS No.: 3118558-91-8
- Formula:C21H24N2O
- Molecular Weight:320.43
InChIKey: ORHUFKXGDKBPSZ-HXUWFJFHSA-N
SMILES: CN1CC2=CC=CC=C2C[C@@H]1CNC(C3CC(C=CC=C4)=C4C3)=O
Biological Activity: BPR1M492 is a brain-penetrant μ-opioid receptor (MOR) agonist an in vitro EC50 of 0.93 nM in the cAMP inhibition assay and 0.004 nM in the FLIPR Ca2+ assay without a clear signaling bias between cAMP and β-arrestin-2 pathway. BPR1M492 is a cAMP-biased nociceptin-orphanin FQ opioid peptide agonist. BPR1M492 is a weak cAMP-biased δ/κ-opioid receptor agonist. BPR1M492 demonstrates potent in vivo antinociception and can be used for pain research[1].
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BPR1M492 | BPR1M492 is a brain-penetrant μ-opioid receptor (MOR) agonist an in vitro EC50 of 0.93 nM in the cAMP inhibition assay and 0.004 nM in the FLIPR Ca2+ assay without a clear signaling bias between cAMP and β-arrestin-2 pathway. BPR1M492 is a cAMP-biased nociceptin-orphanin FQ opioid peptide agonist. BPR1M492 is a weak cAMP-biased δ/κ-opioid receptor agonist. BPR1M492 demonstrates potent in vivo antinociception and can be used for pain research. | |||||||||||||||||||||
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