3119675-75-8
3119675-75-8
Chemical Structure
BTK-IN-52
- CAS No.: 3119675-75-8
- Formula:C26H22Cl2N4O4
- Molecular Weight:525.38
InChIKey: HLXSQUNQKQXJQX-UHFFFAOYSA-N
SMILES: O=C(NNC(CC1=CC=C(Cl)C=C1Cl)=O)C2=CC=C(NC3=CC=NC4=CC(OC)=C(OC)C=C34)C=C2
Biological Activity: BTK-IN-52 is a BTK inhibitor with an IC50 of 126.70 nM. BTK-IN-52 inhibits BTK phosphorylation, induces G0/G1 cell cycle arrest and apoptosis (apoptosis) in cancer cells, and inhibits cancer cell proliferation. BTK-IN-52 inhibits tumor growth in xenograft models. BTK-IN-52 inhibits off-target TEC and JAK2 kinases in selectivity assays. BTK-IN-52 can be used in research related to hematological diseases and lymphoma[1].
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BTK-IN-52 | BTK-IN-52 is a BTK inhibitor with an IC50 of 126.70 nM. BTK-IN-52 inhibits BTK phosphorylation, induces G0/G1 cell cycle arrest and apoptosis (apoptosis) in cancer cells, and inhibits cancer cell proliferation. BTK-IN-52 inhibits tumor growth in xenograft models. BTK-IN-52 inhibits off-target TEC and JAK2 kinases in selectivity assays. BTK-IN-52 can be used in research related to hematological diseases and lymphoma. | |||||||||||||||||||||
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