3120155-78-1
3120155-78-1
Chemical Structure
EGFR/BRAFV600E-IN-6
- CAS No.: 3120155-78-1
- Formula:C28H21N5O3S
- Molecular Weight:507.56
InChIKey: SYIZCKCODVXFJJ-UHFFFAOYSA-N
SMILES: COC(C=C1)=CC=C1C2=C(C#N)C(NC(C(C=C3)=CC=C3NC(CSC4=NC5=CC=CC=C5N4)=O)=C2)=O
Biological Activity: EGFR/BRAFV600E-IN-6 (Compound 7c) is a dual EGFR/BRAFV600E inhibitor with IC50 values of 0.12 and 0.05 μM. EGFR/BRAFV600E-IN-6 can activate caspase-3/8/9, unregulate Bax expression and downregulate Bcl-2 levels. EGFR/BRAFV600E-IN-6 can induce apoptosis and shows antioxidant activity. EGFR/BRAFV600E-IN-6 can be used for the research of cancer, such as colon cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
EGFR/BRAFV600E-IN-6 | EGFR/BRAFV600E-IN-6 (Compound 7c) is a dual EGFR/BRAFV600E inhibitor with IC50 values of 0.12 and 0.05 μM. EGFR/BRAFV600E-IN-6 can activate caspase-3/8/9, unregulate Bax expression and downregulate Bcl-2 levels. EGFR/BRAFV600E-IN-6 can induce apoptosis and shows antioxidant activity. EGFR/BRAFV600E-IN-6 can be used for the research of cancer, such as colon cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
