3120759-70-5
Chemical Structure
BPN-37440
- CAS No.: 3120759-70-5
- Formula:C21H22N4O
- Molecular Weight:346.43
InChIKey: BFOJGOHSTXPEKJ-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(C(C)=NC=C2)N1C)NCCC3=C(C)NC4=CC=CC=C43
Biological Activity: BPN-37440 is a blood-brain barrier-permeable, selective, and orally active EP2 receptor inhibitor with an IC50 of 53-60 nM. BPN-37440 inhibits the expression of inflammatory mediators IL-1β and COX-2, with an IC50 of 21 nM for IL-1β and 42 nM for COX-2. BPN-37440 reduces microgliosis in key brain regions of mice with pilocarpine (HY-B0726A)-induced status epilepticus and reverses their working memory and recognition memory deficits. BPN-37440 can be used for research on status epilepticus[1].
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BPN-37440 | BPN-37440 is a blood-brain barrier-permeable, selective, and orally active EP2 receptor inhibitor with an IC50 of 53-60 nM. BPN-37440 inhibits the expression of inflammatory mediators IL-1β and COX-2, with an IC50 of 21 nM for IL-1β and 42 nM for COX-2. BPN-37440 reduces microgliosis in key brain regions of mice with pilocarpine (HY-B0726A)-induced status epilepticus and reverses their working memory and recognition memory deficits. BPN-37440 can be used for research on status epilepticus. | |||||||||||||||||||||
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