3121511-18-7
Chemical Structure
LHA675
- CAS No.: 3121511-18-7
- Formula:C41H52N2Si
- Molecular Weight:600.95
InChIKey: NXWGECSKWXIXHC-HMZBKAONSA-N
SMILES: C/C(CC1=CC=CC=C1)=C\CC2(C3=CC=CC=C3)C4=C([Si](C)(C)C5=C2C=CC(CN(CC)CC)=C5)C=C(N(CC)CC)C=C4
Biological Activity: LHA675 is a fluorescent probe for early detection of ferroptosis. LHA675 mimics polyunsaturated lipids via a 4-phenyl-3-methylbut-2-enyl group to specifically detect highly oxidative radicals associated with ferroptosis, and releases a fluorophore after the reaction. LHA675 has excitation and emission wavelengths of 647 nm and 663-738 nm, respectively. LHA675 enables wash-free labeling of ferroptosis in living cells; the generated fluorophore localizes to mitochondria and emits deep red fluorescence. LHA675 can be used in studies related to the early detection of ferroptosis[1].
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LHA675 | LHA675 is a fluorescent probe for early detection of ferroptosis. LHA675 mimics polyunsaturated lipids via a 4-phenyl-3-methylbut-2-enyl group to specifically detect highly oxidative radicals associated with ferroptosis, and releases a fluorophore after the reaction. LHA675 has excitation and emission wavelengths of 647 nm and 663-738 nm, respectively. LHA675 enables wash-free labeling of ferroptosis in living cells; the generated fluorophore localizes to mitochondria and emits deep red fluorescence. LHA675 can be used in studies related to the early detection of ferroptosis. | |||||||||||||||||||||
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