3123230-60-1
Chemical Structure
PROTAC sEH degrader-5
- CAS No.: 3123230-60-1
- Formula:C53H70N8O10
- Molecular Weight:979.17
InChIKey: HAROUIUCMOJFFA-OCRIHQAKSA-N
SMILES: O=C(NC12C[C@H](C[C@H](C2)C3)C[C@H]3C1)N[C@H]4CC[C@@H](CC4)OC5=CC=C(C=C5)C(N6CCN(CC6)CC(NCCCCCCCCNC(COC7=CC=CC(C(N8C9C(NC(CC9)=O)=O)=O)=C7C8=O)=O)=O)=O
Biological Activity: PROTAC sEH degrader-5 is a highly efficient PROTAC degrader that targets and degrades soluble epoxide hydrolase (sEH) by recruiting cereblon. PROTAC sEH degrader-5 directly inhibits the hydrolase activity of human and mouse sEH, with pIC50 values of 10.36 and 8.41, respectively. PROTAC sEH degrader-5 alleviates LPS (HY-D1056)-induced acute inflammation in vivo. PROTAC sEH degrader-5 can be used in studies related to LPS-induced acute inflammation[1].
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PROTAC sEH degrader-5 | PROTAC sEH degrader-5 is a highly efficient PROTAC degrader that targets and degrades soluble epoxide hydrolase (sEH) by recruiting cereblon. PROTAC sEH degrader-5 directly inhibits the hydrolase activity of human and mouse sEH, with pIC50 values of 10.36 and 8.41, respectively. PROTAC sEH degrader-5 alleviates LPS (HY-D1056)-induced acute inflammation in vivo. PROTAC sEH degrader-5 can be used in studies related to LPS-induced acute inflammation. | |||||||||||||||||||||
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