3125240-35-6
3125240-35-6
Chemical Structure
PROTAC ALK5 Degrader-1
- CAS No.: 3125240-35-6
- Formula:C43H43ClFN9O7
- Molecular Weight:852.31
InChIKey: NDHAXVNIEULBRH-UHFFFAOYSA-N
SMILES: ClC1=CC(C2=CC(N3C4=CC=NC=C4N(CC(NCCN5CCN(CCCCOC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)CC5)=O)C3=O)=C(C)C=N2)=C(F)C=C1
Biological Activity: PROTAC ALK5 Degrader-1 is a selective ALK5 PROTAC degrader. PROTAC ALK5 Degrader-1 induces ALK5 degradation via ALK5 ATP-binding pocket engagement, CRBN recruitment, and the ubiquitin-proteasome system.PROTAC ALK5 Degrader-1 inhibits ALK5 downstream signaling. PROTAC ALK5 Degrader-1 can be used for the research of pulmonary fibrosis[1].
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PROTAC ALK5 Degrader-1 | PROTAC ALK5 Degrader-1 is a selective ALK5 PROTAC degrader. PROTAC ALK5 Degrader-1 induces ALK5 degradation via ALK5 ATP-binding pocket engagement, CRBN recruitment, and the ubiquitin-proteasome system.PROTAC ALK5 Degrader-1 inhibits ALK5 downstream signaling. PROTAC ALK5 Degrader-1 can be used for the research of pulmonary fibrosis. | |||||||||||||||||||||
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