3125957-10-7
Chemical Structure
ClpP activator-2
- CAS No.: 3125957-10-7
- Formula:C23H21F5N4O
- Molecular Weight:464.43
InChIKey: QLRPUKOSGYNQPQ-UHFFFAOYSA-N
SMILES: O=C1NC(N(C)CC2=CC=C(C(F)(F)F)C=C2)=NC3=C1CN(CC3)CC4=CC(F)=CC(F)=C4
Biological Activity: ClpP activator-2 (Compound GU18) is a ClpP activator with a Kd of 5.01 μM for HsClpP. ClpP activator-2 enhances the proteolytic activity of HsClpP and promotes the degradation of α-casein by HsClpP, with an EC50 of 1.09 μM. ClpP activator-2 induces the accumulation of mitochondrial reactive oxygen species (ROS), leading to damage to mitochondrial structure and function. ClpP activator-2 exhibits significant in vivo anti-multiple myeloma activity[1].
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ClpP activator-2 | ClpP activator-2 (Compound GU18) is a ClpP activator with a Kd of 5.01 μM for HsClpP. ClpP activator-2 enhances the proteolytic activity of HsClpP and promotes the degradation of α-casein by HsClpP, with an EC50 of 1.09 μM. ClpP activator-2 induces the accumulation of mitochondrial reactive oxygen species (ROS), leading to damage to mitochondrial structure and function. ClpP activator-2 exhibits significant in vivo anti-multiple myeloma activity. | |||||||||||||||||||||
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