3126555-64-1
3126555-64-1
Chemical Structure
DNMT-IN-5
- CAS No.: 3126555-64-1
- Formula:C16H12BrClO3
- Molecular Weight:367.62
InChIKey: ZNRFTGZPGSVUMP-JKSUJKDBSA-N
SMILES: CO[C@]1(C2=CC=CC=C2)OC3=CC=CC=C3C([C@@]1(Cl)Br)=O
Biological Activity: DNMT-IN-5 is a stable and efficient DNA methyltransferase (DNMT) inhibitor with high stability and high activity with an IC50 of 0.78 nM. DNMT-IN-5 exhibits sub-micromolar DNMT3A inhibitory activity, upregulates the expression of DNMT-targeted genes, impairs cell proliferation, and triggers a critical cell cycle arrest. DNMT-IN-5 can be used for the study of p53-depleted colorectal cancer[1].
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DNMT-IN-5 | DNMT-IN-5 is a stable and efficient DNA methyltransferase (DNMT) inhibitor with high stability and high activity with an IC50 of 0.78 nM. DNMT-IN-5 exhibits sub-micromolar DNMT3A inhibitory activity, upregulates the expression of DNMT-targeted genes, impairs cell proliferation, and triggers a critical cell cycle arrest. DNMT-IN-5 can be used for the study of p53-depleted colorectal cancer. | |||||||||||||||||||||
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