3127143-52-3
Chemical Structure
FGFR3-IN-12
- CAS No.: 3127143-52-3
- Formula:C26H30N8O2
- Molecular Weight:486.57
InChIKey: QIINKDXZQOKKRX-UHFFFAOYSA-N
SMILES: CN1C2=C(C(C3=NC(NC4=C(N(N=C4)CCN5CCOCC5)C)=NC=C3)=C1)C=CC(NC(C=C)=O)=C2
Biological Activity: FGFR3-IN-12 is a selective fibroblast growth factor receptor 3 (FGFR3) inhibitor with an IC50 of 6.8 nM. FGFR3-IN-12 shows an IC50 of 19.2 nM against FGFR3V555M and an IC50 of 16.9 nM against TNK1 (Thirty-eight Negative Kinase 1). FGFR3-IN-12 inhibits cancer cells proliferation and induces caspase-mediated apoptosis. FGFR3-IN-12 exhibits antitumor activity in bladder cancer xenografts mice models. FGFR3-IN-12 can be used for the research of cancer, such as bladder cancer[1].
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FGFR3-IN-12 | FGFR3-IN-12 is a selective fibroblast growth factor receptor 3 (FGFR3) inhibitor with an IC50 of 6.8 nM. FGFR3-IN-12 shows an IC50 of 19.2 nM against FGFR3V555M and an IC50 of 16.9 nM against TNK1 (Thirty-eight Negative Kinase 1). FGFR3-IN-12 inhibits cancer cells proliferation and induces caspase-mediated apoptosis. FGFR3-IN-12 exhibits antitumor activity in bladder cancer xenografts mice models. FGFR3-IN-12 can be used for the research of cancer, such as bladder cancer. | |||||||||||||||||||||
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