312724-83-7
Chemical Structure
YS-01
- CAS No.: 312724-83-7
- Formula:C18H17NO2S
- Molecular Weight:311.40
InChIKey: YSYKRUMSZLHQRC-RVDMUPIBSA-N
SMILES: CC(C)(C)C1=CC=C(C2=N/C(C(O2)=O)=C/C3=CC=CS3)C=C1
Biological Activity: YS-01 is an inhibitor of pendrin (SLC26A4) with pulmonary protective activity. YS-01 inhibits pendrin-mediated anion exchange activity, reduces pendrin expression, and suppresses the activation of NF-κB and the production of proinflammatory cytokines. YS-01 alleviates lipopolysaccharide-induced and ventilator-induced lung injury. YS-01 attenuates ovalbumin-induced airway hyperresponsiveness, inflammatory infiltration, epithelial thickening and goblet cell hyperplasia, and reduces eosinophil and neutrophil counts. YS-01 decreases MUC5AC transcription levels induced by IL-4, reverses the reduction of airway surface liquid volume, and inhibits the increase of apical SCN− concentration in epithelial cells. YS-01 can be used in studies related to lung injury and allergic asthma[1][2][3].
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YS-01 | YS-01 is an inhibitor of pendrin (SLC26A4) with pulmonary protective activity. YS-01 inhibits pendrin-mediated anion exchange activity, reduces pendrin expression, and suppresses the activation of NF-κB and the production of proinflammatory cytokines. YS-01 alleviates lipopolysaccharide-induced and ventilator-induced lung injury. YS-01 attenuates ovalbumin-induced airway hyperresponsiveness, inflammatory infiltration, epithelial thickening and goblet cell hyperplasia, and reduces eosinophil and neutrophil counts. YS-01 decreases MUC5AC transcription levels induced by IL-4, reverses the reduction of airway surface liquid volume, and inhibits the increase of apical SCN− concentration in epithelial cells. YS-01 can be used in studies related to lung injury and allergic asthma. | |||||||||||||||||||||
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References
- [1]. Lee EH, et al. Inhibition of Pendrin by a small molecule reduces Lipopolysaccharide-induced acute Lung Injury. Theranostics. 2020;10(22):9913-9922. [Content Brief]
- [2]. Choi JS, et al. Pendrin inhibition is associated with protective effect of prone positioning in a ventilator-induced lung injury mouse model. Scientific reports. 2025 Nov 20;15(1):40926. [Content Brief]
- [3]. Park J, et al. Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma. Letter to the Editor, 2019, 144(5): 1425-1428.E12.
