3128034-48-7
Chemical Structure
tP4-CPP12
- CAS No.: 3128034-48-7
- Formula:C145H199N39O25
- Molecular Weight:2888.38
InChIKey: HFHGYNLWPWKAOB-DFAFFJOMSA-N
SMILES: O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N6[C@@H](CCC6)C(N7[C@@H](CCC7)C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CO)C(NCCCC[C@H](NC(CC[C@@H](C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H]%10CC%11=CC=CC=C%11)=O)=O)NC([C@@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC%12=CC(C=CC=C%13)=C%13C=C%12)NC%10=O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
Biological Activity: tP4-CPP12 is a RMI1/2 heterodimer inhibitor with an IC50 of 110 nM. tP4-CPP12 binds competitively at the FANCM-RMI interaction site and disrupts endogenous FANCM-RMI protein-protein interactions. tP4-CPP12 induces antiproliferative effects in ALT-positive osteosarcoma cells. tP4-CPP12 is applicable for the research of ALT-positive osteosarcoma[1].
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tP4-CPP12 | tP4-CPP12 is a RMI1/2 heterodimer inhibitor with an IC50 of 110 nM. tP4-CPP12 binds competitively at the FANCM-RMI interaction site and disrupts endogenous FANCM-RMI protein-protein interactions. tP4-CPP12 induces antiproliferative effects in ALT-positive osteosarcoma cells. tP4-CPP12 is applicable for the research of ALT-positive osteosarcoma. | |||||||||||||||||||||
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