3128784-74-4
3128784-74-4
Chemical Structure
PROTAC SHP2 degrader-1
- CAS No.: 3128784-74-4
- Formula:C38H48Cl3N7O4
- Molecular Weight:773.19
InChIKey: QIZAUOJUPTZKFA-UHFFFAOYSA-N
SMILES: ClC1=C(Cl)C(C2=NC=C(N3CCC(NC(CCCCCCCCNC(COC4=CC=C(N(C(CCl)=O)CCC5)C5=C4)=O)=O)(C)CC3)N=C2N)=CC=C1
Biological Activity: PROTAC SHP2 degrader-1 is a potent SHP2 PROTAC degrader with a DC50 of 7.406 μM. PROTAC SHP2 degrader-1 recruits DCAF16 E3 ligase to induce ubiquitination and proteasomal degradation of SHP2, thereby inhibiting the RAS/MAPK and PI3K/AKT/mTOR signaling pathways while simultaneously inducing IFN-γ/JAK/STAT1, apoptosis, and cell cycle arrest. PROTAC SHP2 degrader-1 can be used for cancer research[1].
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PROTAC SHP2 degrader-1 | PROTAC SHP2 degrader-1 is a potent SHP2 PROTAC degrader with a DC50 of 7.406 μM. PROTAC SHP2 degrader-1 recruits DCAF16 E3 ligase to induce ubiquitination and proteasomal degradation of SHP2, thereby inhibiting the RAS/MAPK and PI3K/AKT/mTOR signaling pathways while simultaneously inducing IFN-γ/JAK/STAT1, apoptosis, and cell cycle arrest. PROTAC SHP2 degrader-1 can be used for cancer research. | |||||||||||||||||||||
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