3128953-16-9
Chemical Structure
TEAD-IN-21
- CAS No.: 3128953-16-9
- Formula:C16H15F3N6O2S
- Molecular Weight:412.39
IUPAC Name: N-(3-(2-methyl-2H-tetrazol-5-yl)-4-((4-(trifluoromethyl)phenyl)amino)phenyl)methanesulfonamide
InChIKey: GYQXCINWRIQUCT-UHFFFAOYSA-N
SMILES: CS(=O)(NC1=CC=C(NC2=CC=C(C(F)(F)F)C=C2)C(C3=NN(C)N=N3)=C1)=O
Biological Activity: TEAD-IN-21 is a potent and orally active pan-TEAD inhibitor with an IC50 of 3 nM. TEAD-IN-21 effectively inhibited the proliferation of Huh-7 cells. TEAD-IN-21 selectively downregulates TEAD-dependent downstream genes. TEAD-IN-21 achieves tumor regression in a liver cancer-derived tumor xenograft mice model. TEAD-IN-21 can be used in the research of hepatocellular carcinoma (HCC)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
TEAD-IN-21 | TEAD-IN-21 is a potent and orally active pan-TEAD inhibitor with an IC50 of 3 nM. TEAD-IN-21 effectively inhibited the proliferation of Huh-7 cells. TEAD-IN-21 selectively downregulates TEAD-dependent downstream genes. TEAD-IN-21 achieves tumor regression in a liver cancer-derived tumor xenograft mice model. TEAD-IN-21 can be used in the research of hepatocellular carcinoma (HCC). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
