3132577-16-0
Chemical Structure
TBC1D2-IN-1
- CAS No.: 3132577-16-0
- Formula:C34H35F3N2O3
- Molecular Weight:576.65
InChIKey: QIZQYNCCLLEFID-OYPJZQSISA-N
SMILES: O=C1N(C[C@@]2([H])[C@@]3([H])[C@]4([H])CCCN3CCC2)[C@]4([H])CC/C1=C\C5=CC(C=CC(OCC6=CC=C(OC(F)(F)F)C=C6)=C7)=C7C=C5
Biological Activity: TBC1D2-IN-1 is a potent orally active and selective TBC1D2 inhibitor with a Kd of 1.1 μM. TBC1D2-IN-1 selectively inhibits TBC1D2-mediated GTP hydrolysis on RAB7A-GTP, promotes RAB7A accumulation on lysosomal membranes, and induces apoptosis and autophagy. TBC1D2-IN-1 exerts selective antiproliferative activity cancer cells. TBC1D2-IN-1 can be used for the research of cervical carcinoma[1].
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TBC1D2-IN-1 | TBC1D2-IN-1 is a potent orally active and selective TBC1D2 inhibitor with a Kd of 1.1 μM. TBC1D2-IN-1 selectively inhibits TBC1D2-mediated GTP hydrolysis on RAB7A-GTP, promotes RAB7A accumulation on lysosomal membranes, and induces apoptosis and autophagy. TBC1D2-IN-1 exerts selective antiproliferative activity cancer cells. TBC1D2-IN-1 can be used for the research of cervical carcinoma. | |||||||||||||||||||||
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