3132870-44-8
Chemical Structure
Rezetecan-Cys
Synonym(s): SHR9265-Cys
- CAS No.: 3132870-44-8
- Formula:C58H67FN10O15S
- Molecular Weight:1195.27
IUPAC Name: 3-phenylpiperidine-2,6-dione
InChIKey: VGNZNGFYKWEVAX-NEOMSDBUSA-N
SMILES: O=C(O)[C@@H](N)CSC(C1)C(N(CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCO[C@H](C3CC3)C(N[C@H]4CCC5=C6C4=C(CN7C(C(COC([C@@]8(CC)O)=O)=C8C=C79)=O)C9=NC6=CC(F)=C5C)=O)=O)=O)=O)=O)=O)C1=O)=O
Biological Activity: Rezetecan-Cys (SHR9265-Cys) is a Cys-modified form of Rezetecan (HY-148668). Rezetecan is a topoisomerase I inhibitor with cytotoxicity. Rezetecan can be used as a toxic payload for antibody-drug conjugates, such as in the synthesis of Tizetatug rezetecan (HY-177711). Rezetecan can be used in research related to various cancers, including breast cancer and gastric cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Rezetecan-Cys | 98.90% | Rezetecan-Cys (SHR9265-Cys) is a Cys-modified form of Rezetecan (HY-148668). Rezetecan is a topoisomerase I inhibitor with cytotoxicity. Rezetecan can be used as a toxic payload for antibody-drug conjugates, such as in the synthesis of Tizetatug rezetecan (HY-177711). Rezetecan can be used in research related to various cancers, including breast cancer and gastric cancer. | ||||||||||||||||||||
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References
- [1]. Zhang T, et al. Abstract LB031: SHR-A1811, a novel anti-HER2 ADC with superior bystander effect, optimal DAR and favorable safety profiles. Cancer Research, 2023, 83(8_Supplement): LB031.
- [2]. Wang B, et al. Preclinical activity of SHR-A1921, a novel antibody-drug conjugate targeting trophoblast cell-surface antigen2 (Trop-2) in prostate cancer. Frontiers in pharmacology. 2026;17:1713983. [Content Brief]
