3133073-71-6
3133073-71-6
Chemical Structure
p53 DUBTAC modulator-1
- CAS No.: 3133073-71-6
- Formula:C34H36IN5O5
- Molecular Weight:721.58
InChIKey: SJPZUHVEAMIUNC-UHFFFAOYSA-N
SMILES: C=CC(N1CCN(C(C1)=O)C2=CC=C(O2)CCC(N3CCN(CC3)CC4=CC(C#CCNC5=CC=CC=C5)=CC(I)=C4O)=O)=O
Biological Activity: p53 DUBTAC modulator-1 (Compound A1) is a p53 Y220C DUBTAC modulator (Kd = 12.09 µM). p53 DUBTAC modulator-1 effectively reactivates and deubiquitinates mutant p53 Y220C. p53 DUBTAC modulator-1 upregulates p53 Y220C protein levels. p53 DUBTAC modulator-1 induces Apoptosis, reduces Bcl-2, inhibits Wnt signaling. p53 DUBTAC modulator-1 has anti-cancer activity against liver cancer[1].
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p53 DUBTAC modulator-1 | p53 DUBTAC modulator-1 (Compound A1) is a p53 Y220C DUBTAC modulator (Kd = 12.09 µM). p53 DUBTAC modulator-1 effectively reactivates and deubiquitinates mutant p53 Y220C. p53 DUBTAC modulator-1 upregulates p53 Y220C protein levels. p53 DUBTAC modulator-1 induces Apoptosis, reduces Bcl-2, inhibits Wnt signaling. p53 DUBTAC modulator-1 has anti-cancer activity against liver cancer. | |||||||||||||||||||||
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