3135086-44-8
Chemical Structure
PROTAC CDK4/6/9 degrader 1 prodrug
- CAS No.: 3135086-44-8
- Formula:C64H86N12O9
- Molecular Weight:1167.44
InChIKey: AXEFWTFIVYSXPB-UHFFFAOYSA-N
SMILES: O=C(N(C)C)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(C=C4)C(CN5CCN(CC5)CC6CCN(CC6)CC(N7CCN(CC7)C8=CC9=C(C=C8)C(N(C9=O)C(C(N%10COC(CCCCCCCCCCC)=O)=O)CCC%10=O)=O)=O)=O
Biological Activity: PROTAC CDK4/6/9 degrader 1 prodrug is an orally active CDK4/CDK6/CDK9 PROTAC degrader prodrug. PROTAC CDK4/6/9 degrader 1 prodrug converts into PROTAC CDK4/6/9 degrader 1 (HY-178452). PROTAC CDK4/6/9 degrader 1 degrades CDK4, CDK6 and CDK9. PROTAC CDK4/6/9 degrader 1 prodrug is applicable to the research of triple-negative breast cancer (prodrug modification moiety: Lauric acid (HY-Y0366); PROTAC moiety: PROTAC CDK4/6/9 degrader 1 (HY-178452))[1].
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PROTAC CDK4/6/9 degrader 1 prodrug | PROTAC CDK4/6/9 degrader 1 prodrug is an orally active CDK4/CDK6/CDK9 PROTAC degrader prodrug. PROTAC CDK4/6/9 degrader 1 prodrug converts into PROTAC CDK4/6/9 degrader 1 (HY-178452). PROTAC CDK4/6/9 degrader 1 degrades CDK4, CDK6 and CDK9. PROTAC CDK4/6/9 degrader 1 prodrug is applicable to the research of triple-negative breast cancer (prodrug modification moiety: Lauric acid (HY-Y0366); PROTAC moiety: PROTAC CDK4/6/9 degrader 1 (HY-178452)). | |||||||||||||||||||||
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