313984-77-9
313984-77-9
Chemical Structure
PU02
- CAS No.: 313984-77-9
- Formula:C16H12N4S
- Molecular Weight:292.36
IUPAC Name: 6-((naphthalen-1-ylmethyl)thio)-9H-purine
InChIKey: BGMSTNYJYPSLHN-UHFFFAOYSA-N
SMILES: C12=NC=NC(SCC3=C4C=CC=CC4=CC=C3)=C1N=CN2
Biological Activity: PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively[1][2].
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PU02 | 98.92% | PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively. | ||||||||||||||||||||
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References
- [1]. Sarah M Trattnig, et al. Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J Biol Chem. 2012 Jul 20;287(30):25241-54. [Content Brief]
- [2]. Xiao-Guang Yang, et al. 6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Eur J Pharmacol. 2012 Nov 15;695(1-3):27-33. [Content Brief]
