3141694-07-4
3141694-07-4
Chemical Structure
14-3-3σ/η/ERα stabilizer-1
- CAS No.: 3141694-07-4
- Formula:C21H19N3O2S
- Molecular Weight:377.46
InChIKey: OKYRJCCVSZQTDE-UHFFFAOYSA-N
SMILES: O=C(NCC1=C(C2=CC=CC=C2)C=C(C(N)=N)S1)C(C=C3)=CC4=C3OCC4
Biological Activity: 14-3-3σ/η/ERα stabilizer-1 (compound 11) is a molecular glue that stabilizes the 14-3-3σ/ERα and 14-3-3η/ERα protein-protein interactions. 14-3-3σ/η/ERα stabilizer-1 binds to the 14-3-3σ/η/ERα interface pocket through electrostatic and π-π stacking interactions, significantly stabilizing the protein complex via a bivalent recruitment mechanism[1].
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14-3-3σ/η/ERα stabilizer-1 | 14-3-3σ/η/ERα stabilizer-1 (compound 11) is a molecular glue that stabilizes the 14-3-3σ/ERα and 14-3-3η/ERα protein-protein interactions. 14-3-3σ/η/ERα stabilizer-1 binds to the 14-3-3σ/η/ERα interface pocket through electrostatic and π-π stacking interactions, significantly stabilizing the protein complex via a bivalent recruitment mechanism. | |||||||||||||||||||||
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